[New perspective of acupuncture analgesia: reward of chronic pain relief and related brain reward circuits].

Relief of the chronic pain, as the negative reinforcement of pain, is recognized as a reward and it activates related brain's reward circultries. Brian's reward circuits not only relate to rewards, but also participate in pain process. Currently, the reward effect of acupuncture on chronic pain relief and the mechanism of brain's reward circuits involved in acupuncture analgeisa have not been revealed adequately yet. This paper reviewed the conceptual features of analgesia reward and the new progression of brain's reward circuits and function, expounded the valuable clinical and scientific significance of the researches for the reward effect of acupuncture analgesia and related brain's reward circuits, proposed the ideas and suggestions on many questions in the study of reward effect of acupuncture analgesia and related brain's reward circuits, and then, determined the multi-dimensional characteristis and positive regulation of acupuncture analgesia. Focusing on the reward effect of acupuncture and related brain's reward circuits for chronic pain relief, the research on the regulatory effect of acupuncture analgesia will be conductive to deepen the understanding of acupuncture analgies in clinical practice and innovate a research concept of acupuncture analgeis. Eventually, a new approach can be provided to further elaborate neurobiolgical mechanism of acupuncture analgesia.慢性痛的缓解作为疼痛的负性强化, 被认为是一种奖赏, 激活大脑奖赏系统。脑内的奖赏环路不仅涉及奖赏, 而且参与疼痛过程。目前针刺缓解慢性痛的奖赏效应和脑内奖赏环路参与针刺镇痛的机制研究尚不充分。本文综述了镇痛奖赏的概念特点、脑奖赏环路及功能的研究新进展, 阐述了研究针刺镇痛的奖赏效应和相关脑奖赏环路的重要临床和科学意义, 对针刺镇痛奖赏效应和相关奖赏环路的若干研究问题提出看法和建议, 进一步明确针刺镇痛的多维性特点和良性调节作用。从针刺缓解慢性痛的奖赏效应及脑内奖赏环路对针刺镇痛的调节作用展开研究工作, 将有助于加深临床上对针刺镇痛的认识, 创新针刺镇痛的研究理念, 为进一步阐明针刺镇痛的神经生物学机制提供新思路。.