5-Year Outcomes of PCI Guided by Measurement of Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve

医学 部分流量储备 血运重建 心脏病学 内科学 传统PCI 心肌梗塞 临床终点 随机对照试验 血管成形术 经皮冠状动脉介入治疗 冠状动脉造影
作者
Matthias Götberg,Karolina Berntorp,Rebecca Rylance,Evald Høj Christiansen,Troels Yndigegn,Ingibjörg Guðmundsdóttir,Sasha Koul,Lennart Sandhall,Mikael Danielewicz,Lars Jakobsen,S. Bertil Olsson,Hans Olsson,Elmir Ömerovic,Fredrik Calais,Pontus Lindroos,Michael Mæng,Dimitrios Venetsanos,Stefan James,Amra Kåregren,Jörg Carlsson,Jens Jensen,Ann-Charlotte Karlsson,David Erlinge,Ole Fröbert
出处
期刊:Journal of the American College of Cardiology [Elsevier BV]
卷期号:79 (10): 965-974 被引量:32
标识
DOI:10.1016/j.jacc.2021.12.030
摘要

Instantaneous wave-free ratio (iFR) is a coronary physiology index used to assess the severity of coronary artery stenosis to guide revascularization. iFR has previously demonstrated noninferior short-term outcome compared to fractional flow reserve (FFR), but data on longer-term outcome have been lacking.The purpose of this study was to investigate the prespecified 5-year follow-up of the primary composite outcome of all-cause mortality, myocardial infarction, and unplanned revascularization of the iFR-SWEDEHEART trial comparing iFR vs FFR in patients with chronic and acute coronary syndromes.iFR-SWEDEHEART was a multicenter, controlled, open-label, registry-based randomized clinical trial using the Swedish Coronary Angiography and Angioplasty Registry for enrollment. A total of 2,037 patients were randomized to undergo revascularization guided by iFR or FFR.No patients were lost to follow-up. At 5 years, the rate of the primary composite endpoint was 21.5% in the iFR group and 19.9% in the FFR group (HR: 1.09; 95% CI: 0.90-1.33). The rates of all-cause death (9.4% vs 7.9%; HR: 1.20; 95% CI: 0.89-1.62), nonfatal myocardial infarction (5.7% vs 5.8%; HR: 1.00; 95% CI: 0.70-1.44), and unplanned revascularization (11.6% vs 11.3%; HR: 1.02; 95% CI: 0.79-1.32) were also not different between the 2 groups. The outcomes were consistent across prespecified subgroups.In patients with chronic or acute coronary syndromes, an iFR-guided revascularization strategy was associated with no difference in the 5-year composite outcome of death, myocardial infarction, and unplanned revascularization compared with an FFR-guided revascularization strategy. (Evaluation of iFR vs FFR in Stable Angina or Acute Coronary Syndrome [iFR SWEDEHEART]; NCT02166736).
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