Neuroinflammation and Proinflammatory Cytokines in Epileptogenesis

癫痫发生 神经炎症 癫痫 促炎细胞因子 神经科学 医学
作者
Alireza Soltani Khaboushan,Niloufar Yazdanpanah,Nima Rezaei
出处
期刊:Molecular Neurobiology [Springer Nature]
标识
DOI:10.1007/s12035-022-02725-6
摘要

Increasing evidence corroborates the fundamental role of neuroinflammation in the development of epilepsy. Proinflammatory cytokines (PICs) are crucial contributors to the inflammatory reactions in the brain. It is evidenced that epileptic seizures are associated with elevated levels of PICs, particularly interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), which underscores the impact of neuroinflammation and PICs on hyperexcitability of the brain and epileptogenesis. Since the pathophysiology of epilepsy is unknown, determining the possible roles of PICs in epileptogenesis could facilitate unraveling the pathophysiology of epilepsy. About one-third of epileptic patients are drug-resistant, and existing treatments only resolve symptoms and do not inhibit epileptogenesis; thus, treatment of epilepsy is still challenging. Accordingly, understanding the function of PICs in epilepsy could provide us with promising targets for the treatment of epilepsy, especially drug-resistant type. In this review, we outline the role of neuroinflammation and its primary mediators, including IL-1β, IL-1α, IL-6, IL-17, IL-18, TNF-α, and interferon-γ (IFN-γ) in the pathophysiology of epilepsy. Furthermore, we discuss the potential therapeutic targeting of PICs and cytokine receptors in the treatment of epilepsy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
seannnnnnn完成签到,获得积分10
刚刚
wuliumu发布了新的文献求助10
刚刚
lunar完成签到,获得积分10
1秒前
NexusExplorer应助kourosz采纳,获得10
1秒前
咕咕咕完成签到,获得积分10
1秒前
1秒前
CooperLI发布了新的文献求助10
1秒前
Enkcy发布了新的文献求助10
1秒前
1秒前
KIORking完成签到,获得积分10
2秒前
77发布了新的文献求助50
3秒前
田様应助细腻冰岚采纳,获得10
3秒前
lida完成签到,获得积分10
3秒前
3秒前
Owen应助AA采纳,获得10
3秒前
zhangJL发布了新的文献求助10
3秒前
Devoted完成签到,获得积分20
4秒前
4秒前
4秒前
FashionBoy应助快乐的雨竹采纳,获得10
5秒前
5秒前
5秒前
叶长亭完成签到,获得积分10
5秒前
perovskite完成签到,获得积分10
5秒前
azure发布了新的文献求助10
5秒前
6秒前
6秒前
丘比特应助依依一一采纳,获得10
6秒前
无花果应助动听从寒采纳,获得10
7秒前
7秒前
36456657应助血小板采纳,获得10
7秒前
抹茶肥肠发布了新的文献求助10
8秒前
丘比特应助xiaox采纳,获得10
8秒前
SYLH应助aqa采纳,获得10
8秒前
8秒前
爱读爱看发布了新的文献求助10
8秒前
kkjay完成签到,获得积分10
8秒前
9秒前
小白应助叶长亭采纳,获得20
9秒前
linxgyu发布了新的文献求助10
10秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3547058
求助须知:如何正确求助?哪些是违规求助? 3124082
关于积分的说明 9357821
捐赠科研通 2822663
什么是DOI,文献DOI怎么找? 1551622
邀请新用户注册赠送积分活动 723570
科研通“疑难数据库(出版商)”最低求助积分说明 713825