Omentin-1, epicardial fat and coronary artery disease

We read with interest, but concern, the recent article by Harada et al. [ [1] Harada K. Shibata R. Ouchi N. Tokuda Y. Funakubo H. Suzuki M. et al. Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients. Atherosclerosis. 2016 Aug; 251: 299-304 Abstract Full Text Full Text PDF PubMed Scopus (29) Google Scholar ] published in Atherosclerosis, on the association between human omentin-1 expression in epicardial adipose tissue (EAT) and coronary artery disease (CAD). The authors concluded that omentin-1 gene expression in EAT is higher in patients with than in those without CAD. These results are quite unexpected with regard to recently published data. Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patientsAtherosclerosisVol. 251PreviewOmentin, an adipocytokine secreted by visceral adipose tissue, protects against obesity-linked cardiovascular complications. However, little is known about its role in epicardial adipose tissue (EAT) and coronary artery disease (CAD). We investigated the expression of omentin in EAT from CAD subjects. Full-Text PDF Reply to: “Omentin-1, epicardial fat and coronary artery disease”AtherosclerosisVol. 255PreviewWe appreciate the interest that Klein et al. have shown in our work, and thank them for their invaluable comments. We respect the findings of the study by Du et al. [1], which is a comprehensive and meticulous study. In our study, omentin expression in epicardial adipose tissue (EAT) was found to be significantly higher in coronary artery disease (CAD) patients than in non-CAD patients. However, the finding of Du et al. was contradictory to our finding owing to differences in the study populations. Full-Text PDF