Complex silica composite nanomaterials templated with DNA origami

纳米技术 DNA折纸 材料科学 模板 纳米结构 纳米材料 纳米尺度 制作 DNA纳米技术 涂层 多孔性 DNA 化学 复合材料 病理 医学 生物化学 替代医学
作者
Xiaoguo Liu,Fei Zhang,Xinxin Jing,Muchen Pan,Pi Liu,Wei Li,Bowen Zhu,Jiang Li,Hong Chen,Lihua Wang,Jianping Lin,Yan Liu,Dongyuan Zhao,Hao Yan,Chunhai Fan
出处
期刊:Nature [Nature Portfolio]
卷期号:559 (7715): 593-598 被引量:427
标识
DOI:10.1038/s41586-018-0332-7
摘要

Genetically encoded protein scaffolds often serve as templates for the mineralization of biocomposite materials with complex yet highly controlled structural features that span from nanometres to the macroscopic scale1-4. Methods developed to mimic these fabrication capabilities can produce synthetic materials with well defined micro- and macro-sized features, but extending control to the nanoscale remains challenging5,6. DNA nanotechnology can deliver a wide range of customized nanoscale two- and three-dimensional assemblies with controlled sizes and shapes7-11. But although DNA has been used to modulate the morphology of inorganic materials12,13 and DNA nanostructures have served as moulds14,15 and templates16,17, it remains challenging to exploit the potential of DNA nanostructures fully because they require high-ionic-strength solutions to maintain their structure, and this in turn gives rise to surface charging that suppresses the material deposition. Here we report that the Stöber method, widely used for producing silica (silicon dioxide) nanostructures, can be adjusted to overcome this difficulty: when synthesis conditions are such that mineral precursor molecules do not deposit directly but first form clusters, DNA-silica hybrid materials that faithfully replicate the complex geometric information of a wide range of different DNA origami scaffolds are readily obtained. We illustrate this approach using frame-like, curved and porous DNA nanostructures, with one-, two- and three-dimensional complex hierarchical architectures that range in size from 10 to 1,000 nanometres. We also show that after coating with an amorphous silica layer, the thickness of which can be tuned by adjusting the growth time, hybrid structures can be up to ten times tougher than the DNA template while maintaining flexibility. These findings establish our approach as a general method for creating biomimetic silica nanostructures.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ran发布了新的文献求助10
2秒前
搜集达人应助大罗采纳,获得10
2秒前
量子星尘发布了新的文献求助10
3秒前
CipherSage应助Dai采纳,获得30
4秒前
科研通AI5应助王佳亮采纳,获得10
6秒前
7秒前
10秒前
英姑应助Sea_U采纳,获得10
11秒前
金金金完成签到,获得积分10
12秒前
cobo完成签到,获得积分10
13秒前
肖肖发布了新的文献求助10
14秒前
Rondab应助准炮打不准采纳,获得10
15秒前
ran完成签到,获得积分10
15秒前
遇上就这样吧应助YSJ采纳,获得10
16秒前
16秒前
朱1591完成签到,获得积分10
18秒前
研友_VZG7GZ应助战斗暴龙兽采纳,获得10
20秒前
20秒前
20秒前
23秒前
YJ888发布了新的文献求助10
23秒前
c_123发布了新的文献求助10
24秒前
SYLH应助科学宝宝☜采纳,获得10
25秒前
clcl发布了新的文献求助10
25秒前
可爱蓝天完成签到,获得积分10
27秒前
顾矜应助东方红采纳,获得30
27秒前
俭朴的听寒完成签到,获得积分10
28秒前
王了了完成签到 ,获得积分10
29秒前
31秒前
kingyz完成签到,获得积分10
31秒前
tan完成签到,获得积分10
33秒前
35秒前
科研通AI5应助张涛采纳,获得10
35秒前
37秒前
37秒前
香蕉觅云应助冉冉采纳,获得10
38秒前
40秒前
yy发布了新的文献求助10
40秒前
41秒前
瘦瘦天奇发布了新的文献求助10
42秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989069
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253589
捐赠科研通 3269939
什么是DOI,文献DOI怎么找? 1804851
邀请新用户注册赠送积分活动 882074
科研通“疑难数据库(出版商)”最低求助积分说明 809073