光热治疗
材料科学
重编程
癌症免疫疗法
免疫疗法
纳米技术
肿瘤微环境
癌症研究
纳米医学
体内
细胞毒性T细胞
免疫系统
体外
免疫学
肿瘤细胞
细胞
医学
纳米颗粒
生物
生物化学
生物技术
遗传学
作者
Lizhen He,Tianqi Nie,Xiaojun Xia,Ting Liu,Yanyu Huang,Xiaojuan Wang,Tianfeng Chen
标识
DOI:10.1002/adfm.201901240
摘要
Abstract Nonspecific absorption and clearance of nanomaterials during circulation is the major cause for treatment failure in nanomedicine‐based cancer therapy. Therefore, herein bioinspired red blood cell (RBC) membrane is employed to camouflage 2D MoSe 2 nanosheets with high photothermal conversion efficiency to achieve enhanced hemocompatibility and circulation time by preventing macrophage phagocytosis. RBC–MoSe 2 ‐potentiated photothermal therapy (PTT) demonstrates potent in vivo antitumor efficacy, which triggers the release of tumor‐associated antigens to activate cytotoxic T lymphocytes and inactivate the PD‐1/PD‐L1 pathway to avoid immunologic escape. Furthermore, in the ablated tumor microenvironment, the tumor‐associated macrophages are effectively reprogrammed to tumoricidal M1 phenotype to potentiate the antitumor action. Taken together, this biomimetic functionalization thus provides a substantial advance in personalized PTT‐triggered immunotherapy for clinical translation.
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