胺化
芳基
卤化物
化学
偶联反应
组合化学
基质(水族馆)
有机化学
催化作用
生物
生态学
烷基
作者
Ruth Dorel,Christian P. Grugel,Alexander M. Haydl
标识
DOI:10.1002/anie.201904795
摘要
The Pd-catalyzed coupling of aryl (pseudo)halides and amines is one of the most powerful approaches for the formation of C(sp2 )-N bonds. The pioneering reports from Migita and subsequently Buchwald and Hartwig on the coupling of aminostannanes and aryl bromides rapidly evolved into general and practical tin-free protocols with broad substrate scope, which led to the establishment of what is now known as the Buchwald-Hartwig amination. This Minireview summarizes the evolution of this cross-coupling reaction over the course of the past 25 years and illustrates some of the most recent applications of this well-established methodology.
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