T细胞受体
主要组织相容性复合体
剧目
免疫学
生物
抗原
免疫系统
人口
次要组织相容性抗原
T细胞
效应器
医学
声学
环境卫生
物理
作者
Dale I. Godfrey,Hui-Fern Koay,James McCluskey,Nicholas A. Gherardin
出处
期刊:Nature Immunology
[Springer Nature]
日期:2019-08-12
卷期号:20 (9): 1110-1128
被引量:423
标识
DOI:10.1038/s41590-019-0444-8
摘要
In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for microbial riboflavin-derivative antigens presented by the major histocompatibility complex (MHC) class I-like protein MR1. MAIT cells use a limited T cell antigen receptor (TCR) repertoire with public antigen specificities that are conserved across species. They can be activated by TCR-dependent and TCR-independent mechanisms and exhibit rapid, innate-like effector responses. Here we review evidence showing that MAIT cells are a key component of the immune system and discuss their basic biology, development, role in disease and immunotherapeutic potential.
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