Intestinal CD36 and Other Key Proteins of Lipid Utilization: Role in Absorption and Gut Homeostasis

Intestinal CD36 and Other Key Proteins of Lipid Utilization: Role in Absorption and Gut Homeostasis Volume 8 Issue 2. April 2018 Vincenza Cifarelli, Vincenza Cifarelli cifarelli@wustl.edu Department of Internal Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USASearch for more papers by this authorNada A. Abumrad, Nada A. Abumrad nabumrad@wustl.edu Department of Internal Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USASearch for more papers by this author Vincenza Cifarelli, Vincenza Cifarelli cifarelli@wustl.edu Department of Internal Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USASearch for more papers by this authorNada A. Abumrad, Nada A. Abumrad nabumrad@wustl.edu Department of Internal Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USASearch for more papers by this author Published online: 26 March 2018 https://doi.org/10.1002/cphy.c170026Citations: 59 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat ABSTRACT Several proteins have been implicated in fatty acid (FA) transport by enterocytes including the scavenger receptor CD36 (SR-B2), the scavenger receptor B1 (SR-B1) a member of the CD36 family and the FA transport protein 4 (FATP4). Here, we review the regulation of enterocyte FA uptake and its function in lipid absorption including prechylomicron formation, assembly and transport. Emphasis is given to CD36, which is abundantly expressed along the digestive tract of rodents and humans and has been the most studied. We also address the pleiotropic functions of CD36 that go beyond lipid absorption and metabolism to include recent evidence of its impact on intestinal homeostasis and barrier maintenance. Areas of progress involving contribution of membrane phospholipid remodeling and of cytosolic FA-binding proteins, FABP1 and FABP2 to fat absorption will be covered. © 2018 American Physiological Society. Compr Physiol 8:493-507, 2018. Citing Literature Comprehensive PhysiologyBrowse other articles of this reference work:BROWSE TABLE OF CONTENTSBROWSE BY TOPICBROWSE A-Z RelatedInformation