白藜芦醇
微生物学
生物膜
大肠杆菌
溶血素
毒力
生物
伞
化学
细菌
药理学
生物化学
基因
遗传学
作者
Jin-Hyung Lee,Yong‐Guy Kim,Chaitany Jayprakash Raorane,Shi Yong Ryu,Jae‐Jin Shim,Jintae Lee
出处
期刊:Biofouling
[Informa]
日期:2019-08-09
卷期号:35 (7): 758-767
被引量:42
标识
DOI:10.1080/08927014.2019.1657418
摘要
Uropathogenic Escherichia coli (UPEC) is the primary causative agent of urinary tract infections, which are one of the most common infectious disease types in humans. UPEC infections involve bacterial cell adhesion to bladder epithelial cells, and UPEC can also form biofilms on indwelling catheters that are often tolerant to common antibiotics. In this study, the anti-biofilm activities of t-stilbene, stilbestrol, t-resveratrol, oxyresveratrol, ε-viniferin, suffruticosol A, and vitisin A were investigated against UPEC. t-Resveratrol, oxyresveratrol, and ε-viniferin, suffruticosol A, and vitisin A significantly inhibited UPEC biofilm formation at subinhibitory concentrations (10–50 μg ml−1). These findings were supported by observations that t-resveratrol and oxyresveratrol reduced fimbriae production and the swarming motility in UPEC. Furthermore, t-resveratrol and oxyresveratrol markedly diminished the hemagglutinating ability of UPEC, and enhanced UPEC killing by human whole blood. The findings show that t-resveratrol, oxyresveratrol, and resveratrol oligomers warrant further attention as antivirulence strategies against persistent UPEC infections.
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