Isolation of benzolactones, Ganodumones A–F from Ganoderma lucidum and their antibacterial activities

Six previously undescribed benzolactone constituents, ganodumones A–F (1–6), a new type of Ganoderma meroterpenoids (GMs) fused with 1,2,3,4,5-pentasubstituted phenyl and 1′,2′-dioxy-3′-methyl-pentyl chain were isolated from the fruiting bodies of Ganoderma lucidum. Their structures were determined by spectroscopic analysis, X-ray crystal diffraction, and ECD computational methods. Meanwhile, bioactive evaluation showed that compounds 3 and 5 have antibacterial activities against Microsporum gypseum with MIC90 56.86 ± 3.98 and 18.48 ± 0.47 μg/mL, respectively.