Cellular Mechanisms of NETosis

中性粒细胞胞外陷阱 先天免疫系统 生物 细胞生物学 炎症 免疫系统 免疫 免疫学
作者
Hawa-Racine Thiam,Siu Ling Wong,Denisa D. Wagner,Clare M. Waterman
出处
期刊:Annual Review of Cell and Developmental Biology [Annual Reviews]
卷期号:36 (1): 191-218 被引量:281
标识
DOI:10.1146/annurev-cellbio-020520-111016
摘要

Neutrophils are critical to innate immunity, including host defense against bacterial and fungal infections. They achieve their host defense role by phagocytosing pathogens, secreting their granules full of cytotoxic enzymes, or expelling neutrophil extracellular traps (NETs) during the process of NETosis. NETs are weblike DNA structures decorated with histones and antimicrobial proteins released by activated neutrophils. Initially described as a means for neutrophils to neutralize pathogens, NET release also occurs in sterile inflammation, promotes thrombosis, and can mediate tissue damage. To effectively manipulate this double-edged sword to fight a particular disease, researchers must work toward understanding the mechanisms driving NETosis. Such understanding would allow the generation of new drugs to promote or prevent NETosis as needed. While knowledge regarding the (patho)physiological roles of NETosis is accumulating, little is known about the cellular and biophysical bases of this process. In this review, we describe and discuss our current knowledge of the molecular, cellular, and biophysical mechanisms mediating NET release as well as open questions in the field.
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