Preclinical Models of Brain Metastasis

Brain metastases have received limited attention in spite of representing a major clinical problem. Difficulties to model this progression of cancer are partially responsible for the limited knowledge of the underlying biology. However, in recent years multiple experimental models have been developed representing the main types of cancer that generate brain metastasis. Although most studies have used non-spontaneous and untreated brain metastasis, more refined versions do exist. We provide an updated review of available and emerging models as well as a discussion regarding their advantages and disadvantages for brain metastasis research.