Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

生物荟萃分析遗传学血压基因等位基因次等位基因频率等位基因频率内科学内分泌学医学

作者

Praveen Surendran,Elena V. Feofanova,Najim Lahrouchi,Ioanna Ntalla,Savita Karthikeyan,James P. Cook,Lingyan Chen,Borbála Mifsud,Chen Yao,Aldi T. Kraja,James Cartwright,Jacklyn N. Hellwege,Ayush Giri,Vinicius Tragante,Guðmar Þorleifsson,Dajiang J. Liu,Bram P. Prins,Isobel D. Stewart,Claudia P. Cabrera,James Eales,Artur Akbarov,Paul L. Auer,Lawrence F. Bielak,Joshua C. Bis,Vickie Braithwaite,Jennifer A. Brody,E. Warwick Daw,Helen R. Warren,Fotios Drenos,Yan V. Sun,Jessica D. Faul,Eric B. Fauman,Cristiano Fava,Teresa Ferreira,Christopher N. Foley,Nora Franceschini,He Gao,Olga Giannakopoulou,Franco Giulianini,Daníel F. Guðbjartsson,Xiuqing Guo,Sarah E. Harris,Aki S. Havulinna,Anna Helgadóttir,Jennifer E. Huffman,Shih‐Jen Hwang,Stavroula Kanoni,Jukka Kontto,Martin G. Larson,Ruifang Li‐Gao,Jaana Lindström,Luca A. Lotta,Yingchang Lu,Jian’an Luan,Anubha Mahajan,Giovanni Malerba,Nicholas G. D. Masca,Hao Mei,Cristina Menni,Dennis O. Mook‐Kanamori,David Mosén-Ansorena,Martina Müller‐Nurasyid,Guillaume Paré,Dirk S. Paul,Markus Perola,Alaitz Poveda,Rainer Rauramaa,Melissa A. Richard,Tom G. Richardson,Nuno Sepúlveda,Xueling Sim,Albert V. Smith,Jennifer A. Smith,James R Staley,Alena Stanáková,Patrick Sulem,Sébastien Thériault,Unnur Þorsteinsdóttir,Stella Trompet,Tibor V. Varga,Digna R. Velez Edwards,Giovanni Veronesi,Stefan Weiß,Sara M. Willems,Jie Yao,Robin Young,Bing Yu,Weihua Zhang,Jinghua Zhao,Wei Zhao,Wei Zhao,Εvangelos Εvangelou,Stefanie Aeschbacher,Eralda Asllanaj,Stefan Blankenberg,Lori L. Bonnycastle,Jette Bork‐Jensen,Ivan Brandslund,Peter S. Braund,Stephen Burgess,Kelly Cho,Cramer Christensen,John Connell,Renée de Mutsert,Anna F. Dominiczak,Marcus Dörr,Guðný Eiríksdóttir,Aliki‐Eleni Farmaki,J. Michael Gaziano,Niels Grarup,Megan L. Grove,Göran Hallmans,Torben Hansen,Christian Theil Have,G. Heiss,Marit E. Jørgensen,Jari Lahti,Eero Kajantie,Mihir Kamat,Annemari Käräjämäki,Fredrik Karpe,Heikki A. Koistinen,Csaba P. Kövesdy,Kari Kuulasmaa,Tiina Laatikainen,Lars Lannfelt,I‐Te Lee,Wen‐Jane Lee,Rudolf A. de Boer,Pim van der Harst,Peter van der Meer,Niek Verweij,Allan Linneberg,Lisa W. Martin,Marie Moitry,Girish N. Nadkarni,Matt J. Neville,Colin N. A. Palmer,George Papanicolaou,Oluf Pedersen,James E. Peters,Neil Poulter,Asif Rasheed,Katrine Laura Rasmussen,Nigel W. Rayner,Reedik Mägi,Frida Renström,Rainer Rettig,Jacques E. Rossouw,Pamela J. Schreiner,Peter Sever,Engilbert Sigurðsson,Tea Skaaby,Yan V. Sun,Johan Sundström,Guðmundur Þorgeirsson,Tõnu Esko,Elisabetta Trabetti,Philip S. Tsao,Jaakko Tuomilehto,Stephen T. Turner,Ioanna Tzoulaki,Ilonca Vaartjes,Anne‐Claire Vergnaud,Cristen J. Willer,Peter W.F. Wilson,Daniel R. Witte,Ekaterina Yonova‐Doing,He Zhang,Naheed Aliya,Peter Almgren,Philippe Amouyel,Folkert W. Asselbergs,Michael R. Barnes,Alexandra I. F. Blakemore,Michael Boehnke,Michiel L. Bots,Erwin P. Böttinger,Julie E. Buring,John C. Chambers,Yii‐Der Ida Chen,Rajiv Chowdhury,David Conen,Adolfo Correa,George Davey Smith,Rudolf A. de Boer,Ian J. Deary,George Dedoussis,Panos Deloukas,Emanuele Di Angelantonio,Paul Elliott,Adam S. Butterworth,John Danesh,Claudia Langenberg,Panos Deloukas,Mark I. McCarthy,Paul W. Franks,Olov Rolandsson,Nicholas J. Wareham,Stephan B. Felix,Jean Ferrières,Ian Ford,Myriam Fornage,Paul W. Franks,Paul W. Franks,Philippe Frossard,Giovanni Gambaro,Tom R. Gaunt,Leif Groop,Vilmundur Guðnason,Tamara B. Harris,Caroline Hayward,Branwen J. Hennig,Karl‐Heinz Herzig,Erik Ingelsson,Jaakko Tuomilehto,Marjo‐Riitta Järvelin,J. Wouter Jukema,Sharon L. R. Kardia,Frank Kee,Jaspal S. Kooner,Charles Kooperberg,Lenore J. Launer,Lars Lind,Ruth J. F. Loos,Abdulla al Shafi Majumder,Markku Laakso,Mark I. McCarthy,Olle Melander,Karen L. Mohlke,Alison D. Murray,Børge G. Nordestgaard,Marju Orho‐Melander,Chris J. Packard,Sandosh Padmanabhan,Walter Palmas,Ozren Polašek,David J. Porteous,Andrew M. Prentice,Michael A. Province,Caroline L. Relton,Kenneth Rice,Paul M. Ridker,Olov Rolandsson,Frits R. Rosendaal,Jerome I. Rotter,Igor Rudan,Veikko Salomaa,Nilesh J. Samani,Naveed Sattar,Wayne H.-H. Sheu,Blair H. Smith,Nicole Soranzo,Timothy D. Spector,John M. Starr,Sylvain Sebért,Kent D. Taylor,Timo A. Lakka,Nicholas J. Timpson,Martin D. Tobin,Bram P. Prins,Eleftheria Zeggini,Pim van der Harst,Peter van der Meer,Ramachandran S. Vasan,Niek Verweij,Jarmo Virtamo,Uwe Völker,David R. Weir,Eleftheria Zeggini,Fadi J. Charchar,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Kelly Cho,J. Michael Gaziano,Csaba P. Kövesdy,Yan V. Sun,Philip S. Tsao,Peter W.F. Wilson,Todd L. Edwards,Adriana M. Hung,Christopher J. O’Donnell,Nicholas J. Wareham,Claudia Langenberg,Maciej Tomaszewski,Adam S. Butterworth,Mark J. Caulfield,John Danesh,Todd L. Edwards,Hilma Hólm,Adriana M. Hung,Cecilia M. Lindgren,Chunyu Liu,Alisa K. Manning,Andrew P. Morris,Alanna C. Morrison,Christopher J. O’Donnell,Bruce M. Psaty,Danish Saleheen,Kāri Stefánsson,Eric Boerwinkle,Daniel I. Chasman,Daniel Levy,Christopher Newton‐Cheh,Patricia B. Munroe,Joanna M. M. Howson

出处

期刊：Nature Genetics [Springer Nature]
日期：2020-11-23 卷期号：52 (12): 1314-1332 被引量：132

链接

nih.gov nih.govdoi.org

标识

DOI：10.1038/s41588-020-00713-x

摘要

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10

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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

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