Trace elements in glaucoma – The impact of analytics

青光眼 微量元素 化学 眼压 环境化学 医学 眼科 有机化学
作者
Bernhard Michalke
出处
期刊:Acta Ophthalmologica [Wiley]
卷期号:97 (S263) 被引量:2
标识
DOI:10.1111/j.1755-3768.2019.8152
摘要

Abstract Eye diseases, such as glaucoma are leading causes of irreversible vision loss in industrialized countries. Eye diseases have multifactorial pathogenesis, where heavy metal body burden and/or trace element misbalances are accepted causes aside from genetic factors or intraocular pressure in glaucoma. Heavy metals and misbalances in redox‐active trace elements are prone to affect eye‐related health via increased oxidative stress. In this study trace elements and heavy metals were analyzed in aqueous humour samples by Flow‐Injection (FI)‐Inductively Coupled Plasma Mass Spectrometry. The FI‐mode was used to adopt sample introduction to the very low sample volume available. Samples were analyzed in triplicates using standard mode (best sensitivity for Co, Cd, Hg, Pb), dynamic reaction cell (DRC) mode with ammonia as reaction gas (interference elimination best for Mn, Fe Cu, Zn) and DRC with methane as reaction gas for Se. 5‐point calibration curves in the ranges 0‐1000 ng/l for Cd, Hg, Mn, Pb, Se or 0‐100 µg/l for Cu, Fe, Zn showed R 2 = 0.989 for Zn and R 2 better than 0.999 for the other elements. Analysis of glaucoma patients revealed an unchanged selenium aqueous humor level of POAG patients compared to controls. However, age‐group and sex dependent trends were seen, i.e. a slight increase for the selenium quantiles in POAG and PEXG patients (age 47–60 years), decrease for the first selenium quantile (61–68 years) and an increase of the third tertiles for 70–85 years.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
9秒前
liuarise发布了新的文献求助10
9秒前
lz完成签到,获得积分10
10秒前
调研昵称发布了新的文献求助10
14秒前
大个应助大巧若拙采纳,获得10
14秒前
14秒前
清川映叶应助科研通管家采纳,获得10
15秒前
小蘑菇应助科研通管家采纳,获得10
15秒前
15秒前
852应助科研通管家采纳,获得10
15秒前
慕青应助科研通管家采纳,获得10
15秒前
SIiveryyyy完成签到,获得积分10
15秒前
15秒前
JamesPei应助科研通管家采纳,获得10
15秒前
15秒前
16秒前
16秒前
17秒前
19秒前
Ting应助RNAPW采纳,获得10
21秒前
22秒前
hyl1115发布了新的文献求助10
23秒前
HBUTL发布了新的文献求助10
23秒前
kuangweiming完成签到,获得积分10
24秒前
尊敬乐蕊完成签到,获得积分10
25秒前
大巧若拙发布了新的文献求助10
26秒前
费老五完成签到 ,获得积分10
30秒前
哈哈发布了新的文献求助10
30秒前
31秒前
李健应助WJY采纳,获得10
34秒前
37秒前
万柏祺完成签到,获得积分10
38秒前
奋斗的晓丝完成签到,获得积分10
38秒前
LSY28发布了新的文献求助20
39秒前
执着易形发布了新的文献求助10
3秒前
3秒前
wwho_O发布了新的文献求助30
4秒前
打打应助不散的和弦采纳,获得10
5秒前
Ting应助狒狒采纳,获得10
7秒前
why发布了新的文献求助10
8秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2000
BIOLOGY OF NON-CHORDATES 1000
进口的时尚——14世纪东方丝绸与意大利艺术 Imported Fashion:Oriental Silks and Italian Arts in the 14th Century 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 550
The Collected Works of Jeremy Bentham: Rights, Representation, and Reform: Nonsense upon Stilts and Other Writings on the French Revolution 320
Med Surg Certification Review Book: 3 Practice Tests and CMSRN Study Guide for the Medical Surgical (RN-BC) Exam [5th Edition] 300
Play from birth to twelve: Contexts, perspectives, and meanings – 3rd Edition 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3358140
求助须知:如何正确求助?哪些是违规求助? 2981312
关于积分的说明 8698638
捐赠科研通 2662919
什么是DOI,文献DOI怎么找? 1458178
科研通“疑难数据库(出版商)”最低求助积分说明 675060
邀请新用户注册赠送积分活动 666078