Probiotics Mucoadhesion: Improved Gastric Acid Resistance and Adhesive Colonization of Probiotics by Mucoadhesive and Intestinal Targeted Konjac Glucomannan Microspheres (Adv. Funct. Mater. 35/2020)

In article number 2001157, Fazheng Ren, Yuan Li, and co-workers demonstrate an intestinal responsive delivery system for improving the viability of probiotics in gastrointestinal conditions using modified Konjac glucomannan. The delivered probiotics survive under gastric conditions and responsively release in the intestine. Then, disintegrated polysaccharides function as a bridge, promoting the adhesion of probiotics to a mucus network, and prolonging their colonization effectively.