Role of Tranexamic Acid in Controlling Blood Loss in Major Orthopaedic Surgeries (TRAMOS): A Comparative Study

Introduction: Tranexamic Acid has been used in major surgeries in various fields of medicine. It has shown to effective in reducing the blood loss during surgery. But it's use in orthopaedic surgeries was limited due to concern regarding efficacy and safety. Material and Method: 54 patients were included in the study during the study period. Patients were randomly allotted to 2 groups of equal participants. The first group (Group A) received Tranexamic Acid. The second group (Group B) was given placebo. The Total Blood Loss and Fall in Haemoglobin levels were measured post-operatively at 24 and 72 hrs of post-operative period. Result: The group A had showed significantly reduced total blood loss and fall in Haemoglobin, thus, requiring less blood transfusions. No complications were noted with tranexamic acid use. Conclusion: We conclude that Tranexamic acid can be effective in reducing blood loss and subsequent fall in haemoglobin. Its judicious use may thus reduce allogenic blood transfusions in major orthopaedic surgeries.