试剂
化学
亲核细胞
反应性(心理学)
催化作用
选择性
卤化物
有机碱
有机化学
组合化学
甲基化
生物化学
医学
基因
病理
替代医学
作者
Pietro Tundo,Alvise Perosa
摘要
Abstract Dimethylcarbonate (DMC) is a valuable methylating reagent that can replace methyl halides and dimethylsulfate in the methylation of a variety of nucleophiles. It couples tunable reactivity and unprecedented selectivity towards mono‐ C‐ and mono‐ N‐ methylation. In addition, it is a prototype example of a green reagent , because it is nontoxic, is made by a clean process, is biodegradable, and reacts in the presence of a catalytic amount of base, thereby avoiding the formation of undesirable inorganic salts as by‐products. Depending on the reaction conditions, DMC can be reacted under plug‐flow, CSTR, or batch conditions. Other remarkable reactions are those where DMC behaves as an oxidant. The reactivity of other carbonates is reported as well. © 2002 The Japan Chemical Journal Forum and John Wiley & Sons, Inc. Chem Rec 2: 13–23, 2002
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