Modular Chemoenzymatic One‐Pot Syntheses in Aqueous Media: Combination of a Palladium‐Catalyzed Cross‐Coupling with an Asymmetric Biotransformation

Two breeds of cat: A palladium-catalyzed Suzuki cross-coupling and an enzymatic reduction with an alcohol dehydrogenase from Rhodococcus sp. together enable the efficient and highly enantioselective synthesis of chiral biaryl alcohols in a one-pot process (see scheme).