信号转导衔接蛋白
生物
细胞生物学
信号转导
MAP激酶激酶激酶
胞浆
调解人
交通2
MAPK/ERK通路
免疫学
肿瘤坏死因子α
生物化学
酶
肿瘤坏死因子受体
作者
Giichi Takaesu,Satoshi Kishida,Akihiko Hiyama,Kyoko Yamaguchi,Hiroshi Shibuyà,Kenji Irie,Jun Ninomiya‐Tsuji,Kunihiro Matsumoto
出处
期刊:Molecular Cell
[Elsevier]
日期:2000-04-01
卷期号:5 (4): 649-658
被引量:587
标识
DOI:10.1016/s1097-2765(00)80244-0
摘要
The TAK1 MAPKKK mediates activation of JNK and NF-κB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-κB activation, whereas a dominant-negative mutant TAB2 impairs their activation by IL-1. IL-1 stimulates translocation of TAB2 from the membrane to the cytosol where it mediates the IL-1-dependent association of TAK1 with TRAF6. These results define TAB2 as an adaptor linking TAK1 and TRAF6 and as a mediator of TAK1 activation in the IL-1 signaling pathway.
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