Higher 25(OH)D2 Is Associated With Lower 25(OH)D3 and 1,25(OH)2D3

维生素D与神经学 内科学 维生素D缺乏 维生素 医学 内分泌学 化学
作者
Christine M. Swanson,Carrie M. Nielson,Smriti Shrestha,Christine G. Lee,Elizabeth Barrett‐Connor,Ivo Jans,Jane A. Cauley,Steven Boonen,Roger Bouillon,Dirk Vanderschueren,Eric Orwoll
出处
期刊:The Journal of Clinical Endocrinology and Metabolism [Oxford University Press]
卷期号:99 (8): 2736-2744 被引量:34
标识
DOI:10.1210/jc.2014-1069
摘要

Despite common use of supplemental vitamin D2 in clinical practice, the associations of serum vitamin D2 concentrations with other vitamin D metabolites and total vitamin D are unclear. The aim of the study was to measure vitamin D2 and D3 levels and examine their associations with each other and with total vitamin D. We performed a cross-sectional analysis of 679 randomly selected participants from the Osteoporotic Fractures in Men Study. 25-Hydroxyvitamin D2 [25(OH)D2], 25(OH)D3, 1,25-dihydroxyvitamin D2 [1,25(OH)2D2], and 1,25(OH)2D3 were measured using liquid chromatography-tandem mass spectrometry and were summed to obtain total 25(OH)D and 1,25(OH)2D. Associations between all metabolites (D2, D3, and total levels) were examined using Wilcoxon rank-sum tests and Spearman correlations. 25(OH)D2 and 1,25(OH)2D2 were detectable in 189 (27.8%) and 178 (26.2%) of the men, respectively. Higher 25(OH)D2 levels did not correlate with higher total 25(OH)D (r = 0.10; P = .17), although median total 25(OH)D was slightly higher in those with detectable vs undetectable 25(OH)D2 (25.8 vs 24.3 ng/mL; P < .001). 25(OH)D2 was not positively associated with total 1,25(OH)2D levels (r = −0.11; P = .13), and median 1,25(OH)2D level was not higher in those with detectable vs undetectable 25(OH)D2. Higher 25(OH)D2 was associated with lower 25(OH)D3 (r = −0.35; P < .001) and 1,25(OH)2D3 (r = −0.32; P < .001), with median levels of both D3 metabolites 18–35% higher when D2 metabolites were undetectable. In a cohort of older men, 25(OH)D2 is associated with lower levels of 25(OH)D3 and 1,25(OH)2D3, suggesting that vitamin D2 may decrease the availability of D3 and may not increase calcitriol levels.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
3秒前
YinLi发布了新的文献求助10
4秒前
小马甲应助阔达金连采纳,获得10
6秒前
科研通AI5应助赵宇宙采纳,获得10
6秒前
merrylake完成签到 ,获得积分10
6秒前
7秒前
7秒前
路越完成签到,获得积分10
7秒前
量子星尘发布了新的文献求助10
9秒前
Constantine完成签到,获得积分10
9秒前
10秒前
运敬完成签到 ,获得积分10
10秒前
11秒前
白日梦发布了新的文献求助10
13秒前
珂泐发布了新的文献求助10
13秒前
14秒前
15秒前
Hh发布了新的文献求助10
17秒前
zzq778发布了新的文献求助10
17秒前
白日梦完成签到,获得积分10
19秒前
19秒前
20秒前
24秒前
习习发布了新的文献求助10
24秒前
25秒前
26秒前
认真如霜完成签到 ,获得积分10
27秒前
zzq778完成签到,获得积分10
27秒前
峰回路转完成签到,获得积分10
28秒前
29秒前
顾雨嘉完成签到,获得积分10
29秒前
miaomiao发布了新的文献求助30
29秒前
龅牙苏发布了新的文献求助10
29秒前
阔达金连完成签到,获得积分10
34秒前
35秒前
量子星尘发布了新的文献求助10
37秒前
miaomiao应助smile采纳,获得10
38秒前
parace发布了新的文献求助10
40秒前
赵宇宙发布了新的文献求助10
41秒前
高分求助中
(禁止应助)【重要!!请各位详细阅读】【科研通的精品贴汇总】 10000
Plutonium Handbook 4000
Qualitative Inquiry and Research Design: Choosing Among Five Approaches 5th Edition 2000
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 1500
Stereoelectronic Effects 1000
Robot-supported joining of reinforcement textiles with one-sided sewing heads 900
Principles of Plasma Discharges and Materials Processing,3rd Edition 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4208780
求助须知:如何正确求助?哪些是违规求助? 3742947
关于积分的说明 11781863
捐赠科研通 3412785
什么是DOI,文献DOI怎么找? 1872818
邀请新用户注册赠送积分活动 927420
科研通“疑难数据库(出版商)”最低求助积分说明 837073