Anti-diabetic activities of Gegen Qinlian Decoction in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes

内分泌学 内科学 汤剂 糖尿病 链脲佐菌素 医学 传统医学 3T3-L1 脂肪细胞 脂肪组织
作者
Changhua Zhang,Guoliang Xu,Lei Zhu,Yi Rao,Riyue Yu,Zhongwei Zhang,Yuesheng Wang,Tao Liang
出处
期刊:Phytomedicine [Elsevier]
卷期号:20 (3-4): 221-229 被引量:67
标识
DOI:10.1016/j.phymed.2012.11.002
摘要

Gegen Qinlian Decoction (GGQLD) is one of the well-known traditional Chinese medicines. Recently, it was reported that GGQLD had good clinical effects on type 2 diabetes mellitus. However, few studies have confirmed in detail the anti-diabetic activities of GGQLD in vivo and in vitro. In the present study, we investigated the anti-diabetic effects of GGQLD in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes. The present results suggested GGQLD (4.95, 11.55 and 18.15 g/kg) decreased significantly fasting blood glucose, glycosylated serum protein, and glycosylated hemoglobin of diabetic rats (p < 0.05), and GGQLD (4.95 and 18.15 g/kg) decreased significantly fasting serum insulin levels of diabetic rats (p < 0.05); in 3T3-L1 adipocytes, Gegen Qinlian Decoction-containing serum (GGQLD-CS) (4%, 8% and 16%) enhanced glucose consumption, triglyceride (TG) content, adiponectin protein concentration and the mRNA expression of adiponectin. Adiponectin contributes to the regulation of lipid and glucose metabolism, and can play a critical role in the development of diabetes mellitus; the mechanisms of action of GGQLD might be related to augmentation of adiponectin protein concentration and up-regulation of the mRNA expression of adiponectin. However, the multi-target mechanisms of action of GGQLD need to be clarified further. The present study further validated the beneficial effects of GGQLD as an anti-diabetic agent. These findings provide a new insight into the anti-diabetic application for GGQLD in clinic and display the potential of GGQLD as a new drug candidate for the treatment of diabetes mellitus.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
完美梨愁发布了新的文献求助20
1秒前
xyg发布了新的文献求助10
3秒前
ClaudiaCY完成签到,获得积分10
3秒前
4秒前
学术大咖完成签到,获得积分10
4秒前
在水一方应助魯蛋采纳,获得10
5秒前
今后应助卢健辉采纳,获得10
5秒前
陈陈陈发布了新的文献求助10
5秒前
5秒前
6秒前
坚强的茗茗完成签到,获得积分10
7秒前
wangtingyu完成签到,获得积分10
8秒前
LFJ发布了新的文献求助10
9秒前
七七发布了新的文献求助10
9秒前
yu发布了新的文献求助10
9秒前
exile完成签到,获得积分10
9秒前
10秒前
11秒前
11秒前
Akim应助xyg采纳,获得10
11秒前
zxd发布了新的文献求助10
12秒前
Dr.c发布了新的文献求助10
12秒前
14秒前
喵卫五更完成签到,获得积分10
14秒前
14秒前
14秒前
abe发布了新的文献求助10
15秒前
15秒前
崽崽在想什么完成签到,获得积分10
16秒前
zk应助快乐的英姑采纳,获得10
16秒前
无花果应助xiatl采纳,获得10
16秒前
17秒前
Sky36001完成签到,获得积分10
17秒前
Owen应助yu采纳,获得10
17秒前
研友_VZG7GZ应助zxd采纳,获得10
17秒前
元谷雪应助动听幻儿采纳,获得10
17秒前
万能图书馆应助Dr.c采纳,获得10
18秒前
小菜鸡发布了新的文献求助10
18秒前
Sky36001发布了新的文献求助10
20秒前
22秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Development of general formulas for bolted flanges, by E.O. Waters [and others] 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3255340
求助须知:如何正确求助?哪些是违规求助? 2897764
关于积分的说明 8297974
捐赠科研通 2566820
什么是DOI,文献DOI怎么找? 1393996
科研通“疑难数据库(出版商)”最低求助积分说明 652669
邀请新用户注册赠送积分活动 630319