生物
脂肪细胞
表皮生长因子
脂肪组织
细胞生物学
跨膜蛋白
细胞分化
脂肪生成
糖基化
串联重复
基因
细胞培养
内分泌学
遗传学
受体
基因组
作者
Cynthia M. Smas,Hei Sook Sul
出处
期刊:Cell
[Elsevier]
日期:1993-05-01
卷期号:73 (4): 725-734
被引量:657
标识
DOI:10.1016/0092-8674(93)90252-l
摘要
With the aim of identifying novel regulators of adipocyte differentiation, we have cloned and characterized preadipocyte factor 1 (pref-1), a novel member of the epidermal growth factor (EGF)-like family of proteins. Pref-1 is synthesized as a transmembrane protein with six tandem EGF-like repeats. In preadipocytes, multiple discrete forms of pref-1 protein of 45–60 kd are present, owing in part to N-linked glycosylation. While pref-1 mRNA is abundant in preadipocytes, its expression is completely abolished during differentiation of 3T3-L1 preadipocytes to adipocytes. Moreover, constitutive expression of pref-1 in preadipocytes, which in effect blocks its down-regulation, drastically inhibits adipose differentiation. This indicates that pref-1 functions as a negative regulator of adipocyte differentiation, possibly in a manner analogous to EGF-like proteins that govern cell fate decisions in invertebrates.
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