神经退行性变
多发性硬化
小胶质细胞
神经科学
线粒体
中枢神经系统
神经炎症
疾病
生物
脱髓鞘病
医学
病理
炎症
免疫学
细胞生物学
作者
Maarten E. Witte,Don Mahad,Hans Lassmann,Jack van Horssen
标识
DOI:10.1016/j.molmed.2013.11.007
摘要
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Current treatments are very effective in reducing the neuroinflammatory attack, but fail to significantly halt disease progression and associated loss of neuronal tissue. In recent years, it has become increasingly clear that dysfunctional mitochondria are important contributors to damage and loss of both axons and neurons. Observations in animal and histopathological studies suggest that infiltrating leukocytes and activated microglia play a central role in neuronal mitochondrial dysfunction. This review provides a comprehensive overview on the current knowledge regarding mitochondrial dysfunction in MS. Importantly, more insight into the cause and consequences of impaired mitochondrial function provide a basis for mitochondrial-targeted medicine to combat progressive MS.
科研通智能强力驱动
Strongly Powered by AbleSci AI