分子信标
化学
核酸
核酸酶
锁核酸
核酸热力学
熔化温度
DNA
核糖核酸
信标
生物化学
生物物理学
寡核苷酸
基序列
复合材料
生物
材料科学
实时计算
计算机科学
作者
Lin Wang,Chaoyong Yang,Colin D. Medley,Steven A. Benner,Weihong Tan
摘要
A novel LNA-MB (molecular beacon based on locked nucleic acid bases) has been designed and investigated. It exhibits very high melting temperature and is thermally stable, shows superior single base mismatch discrimination capability, and is stable against digestion by nuclease and has no binding with single-stranded DNA binding proteins. The LNA-MB will be widely useful in a variety of areas, especially for in vivo hybridization studies.
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