医学
体内
心脏病学
组织学
急性冠脉综合征
内科学
冠状动脉粥样硬化
冠心病
心肌梗塞
生物
生物技术
作者
Angela Pucci,Imad Sheiban,Luisa Formato,Angela Celeste,Elvis Brscic,Claudio Moretti,Alberto De Bernardi,Alessandro Alberti,Laura Bergamasco,G. P. Trevi,Valentín Fuster
标识
DOI:10.1016/j.atherosclerosis.2006.07.026
摘要
Objectives Aim of the study was to investigate whether maintained moderate statin treatment influence atheroma, macrophage content, neoangiogenesis and/or haemorrhage in coronary plaques from patients with non-fatal coronary syndromes. Methods A total of 48 patients underwent elective directional coronary atherectomy on “de novo” culprit lesions; 16 patients had non-treated hypercholesterolemia, 16 patients received maintained moderate statin treatment for hypercholesterolemia and 16 had no lipoprotein abnormalities. These three patients groups were matched for age and clinical diagnosis of stable angina (SA) or unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI). Atherectomy specimens were stained with antibodies against macrophages, endothelial cells and glycophorin A. Results of histology and immunohistochemistry were morphometrically analyzed by using computer-assisted image analysis. Results Atheroma and fibrous tissue, neoangiogenesis, macrophage and haemorrhage (i.e., glycophorin A) differed between the three groups (P < 0.05). Statin-treated group showed significantly decreased atheroma (P = 0.016), fibrous tissue (P = 0.42), macrophage content (P = 0.012), neoangiogenesis (P = 0.00048) and haemorrhage (P = 0.0092) as compared with the non-treated hyperlipidemic group. Conclusions The present findings show that maintained moderate statin treatment may contribute to plaque stabilization in non-fatal coronary syndromes by decreasing intraplaque neoangiogenesis and haemorrhage, lipid burden and macrophage content, and, on the other hand, by increasing plaque collagenization.
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