接种疫苗
免疫学
免疫
获得性免疫系统
异源的
先天免疫系统
免疫系统
生物
细胞因子
白细胞介素12
医学
细胞毒性T细胞
体外
生物化学
基因
作者
Johanneke Kleinnijenhuis,Jessica Quintin,Frank Preijers,Leo A. B. Joosten,Cor Jacobs,Ramnik J. Xavier,J.W.M. van der Meer,Reinout van Crevel,Mihai G. Netea
标识
DOI:10.1016/j.clim.2014.10.005
摘要
Adaptive features of innate immunity, also termed ‘trained immunity’, have recently been shown to characterize monocytes of BCG vaccinated healthy volunteers. Trained immunity leads to increased cytokine production in response to non-related pathogens via epigenetic reprogramming of monocytes. Recently, memory-like properties were also observed in NK cells during viral infections, but it is unknown if memory properties of NK cells contribute to trained immunity due to BCG vaccination. BCG vaccination of healthy volunteers increased proinflammatory cytokine production following ex vivo stimulation of NK cells with mycobacteria and other unrelated pathogens up until at least three months after vaccination. In addition, in a murine model of disseminated candidiasis, BCG vaccination led to an increased survival in SCID mice, which was partially dependent on NK cells. These findings suggest that NK cells may contribute to the non-specific (heterologous) beneficial effects of BCG vaccination.
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