CD8型
主要组织相容性复合体
生物
细胞生物学
化学
免疫学
抗原
标识
DOI:10.1016/s1471-4906(02)02191-9
摘要
CD8 is a coreceptor of T cells for the recognition of peptide–MHC (pMHC) on antigen-presenting cells. It exists in two forms: an αα homodimer and an αβ heterodimer. The different functions of these two forms have long been a mystery, although it is believed that the heterodimer has a stronger affinity than the homodimer for pMHC. The structural basis of the interaction between pMHC and the αα homodimer in humans and mice was determined by X-ray crystallography a few years ago, but no structural explanation for the functional differences between homo- and heterodimers could be deduced. Two recent papers provide some clues on this matter.
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