Radioimmunoassay of β2-Microglobulin in Human Biological Fluids

A radioimmunoassay has been employed for quantitation of β2-microglobulin in human biological fluids. The average β2-microglobulin amounts in serum and urine from 10 healthy subjects were 1.5 mg/1 and 0.073 mg/24 hour volume, respectively, and in serum, saliva, and colostrum from 10 women 1.3, 1.1, and 19.7 mg/1, respectively. A good correlation was observed between the values obtained by radioimmunoassay and by single radial immunodiffusion on concentrates of urinary proteins.