医学
高钾血症
肾脏疾病
盐皮质激素受体
重症监护医学
内科学
2型糖尿病
中止
糖尿病
吡格列酮
不利影响
醛固酮
内分泌学
作者
Alberto Ortíz,Roberto Alcázar Arroyo,Pedro Pablo Casado Escribano,Beatriz Fernández‐Fernández,Francisco Martínez Debén,Juan Diego Mediavilla,Alfredo Michán‐Doña,María José Soler,José Luis Górriz
标识
DOI:10.1080/17512433.2023.2213888
摘要
Introduction Patients with type 2 diabetes (T2DM) and chronic kidney disease (CKD) are at high risk of CKD progression and cardiovascular events. Despite treatment with renin-angiotensin system inhibitors and SGLT-2 inhibitors, the residual risk is substantial. There is preclinical and clinical evidence supporting a key role of mineralocorticoid receptor in cardiorenal injury in T2DM.
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