代谢物
计算生物学
AKT1型
生物
肠道菌群
药理学
信号转导
生物化学
PI3K/AKT/mTOR通路
作者
Ki‐Kwang Oh,Ickwon Choi,Haripriya Gupta,Raja Ganesan,Satya Priya Sharma,Sung‐Min Won,Jin‐Ju Jeong,Su-Been Lee,Min‐Gi Cha,Goo-Hyun Kwon,Min-Kyo Jeong,Byeong-Hyun Min,Ji-Ye Hyun,Jung-A Eom,Hee-Jin Park,Sang Jun Yoon,Mi‐Ran Choi,Dong Joon Kim,Ki Tae Suk
标识
DOI:10.1080/21691401.2022.2155661
摘要
We intended to identify favourable metabolite(s) and pharmacological mechanism(s) of gut microbiota (GM) for liver regeneration (LR) through network pharmacology. We utilized the gutMGene database to obtain metabolites of GM, and targets associated with metabolites as well as LR-related targets were identified using public databases. Furthermore, we performed a molecular docking assay on the active metabolite(s) and target(s) to verify the network pharmacological concept. We mined a total of 208 metabolites in the gutMGene database and selected 668 targets from the SEA (1,256 targets) and STP (947 targets) databases. Finally, 13 targets were identified between 61 targets and the gutMGene database (243 targets). Protein-protein interaction network analysis showed that AKT1 is a hub target correlated with 12 additional targets. In this study, we describe the potential microbe from the microbiota (E. coli), chemokine signalling pathway, AKT1 and myricetin that accelerate LR, providing scientific evidence for further clinical trials.
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