化学
亚硫酸氢盐
羟基化
激进的
生物化学
酶
基因
基因表达
DNA甲基化
作者
Xu Jin,Siyu Yao,Yang Liu,Jin Tang,Minghan Zhu,Hang Liu,Yuanyuan Yu,Xiaolong Yu,Jianteng Sun
出处
期刊:Chemosphere
[Elsevier]
日期:2023-01-04
卷期号:315: 137741-137741
被引量:14
标识
DOI:10.1016/j.chemosphere.2023.137741
摘要
Carbamazepine (CBZ) as an extensively distributed emerging pollutant has menaced ecological security. The degradation performance of CBZ by UV driven bisulfite process was investigated in this work. The kinetics results indicated that CBZ was high-efficiently degraded by UV/bisulfite following a pseudo first-order kinetic model (Kobs = 0.0925 min-1). SO4•- and •OH were verified as the reactive oxidants by EPR test and the radicals scavenging experiment using MeOH and TBA. SO4•- played a dominant role for CBZ degradation. The Density functional theory (DFT) and LC-qTOF-MS/MS clarified that hydroxylation, ketonation, ring opening reaction, and ring contraction were main transformation patterns of CBZ. As to influence factors, CBZ degradation was significantly hindered in presence of CO32-, HPO42- and NOM. Toxicological analysis derived from metabonomics suggested that the remarkable alteration of metabolic profile was triggered by exposure to intermediates mixture. CBZ intermediates interfered in several key metabolic pathways, including pentose phosphate, amino acids, lysine degradation, glycerophospholipid, glutathione, nucleotides and carbohydrate, which was alleviated after UV/bisulfite treatment. This work provided a meaningful support to potential risk of CBZ intermediates products, which shed light on the future application in eliminating drugs using UV /bisulfite.
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