珊瑚
化学
戒指(化学)
立体化学
斑马鱼
生物化学
生物
有机化学
生态学
基因
作者
Cili Wang,Tianyun Jin,Xuehuan Liu,Jiarui Zhang,Xing Shi,Mengfei Wang,RunFeng Huang,Yun Zhang,Kechun Liu,Guoqiang Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-12-07
卷期号:24 (49): 9007-9011
被引量:7
标识
DOI:10.1021/acs.orglett.2c03631
摘要
Five new furanobutenolide-derived C19-norcembranoid diterpenes, sinudenoids A-E (1-5, respectively), were isolated from the soft coral Sinularia densa. Sinudenoid A (1) possesses an uncommon 5/5/11-fused tricyclic ring system. Sinudenoids B-D (2-4, respectively) share the same tetracyclic 5/5/6/6 ring system but represent two kinds of new skeletons. Sinudenoid E (5) is the second compound with the rare 8/8 bicyclic carbon core. A plausible biosynthesis pathway for compounds 1-6 is proposed. Compound 5 exhibits strong anti-inflammatory activity in the zebrafish model.
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