This paper investigates the asymmetric impact of global economic policy uncertainty (GEPU) on global asset allocation. We employ the Double Asymmetric GARCH-MIDAS (DAGM) model to examine the asymmetric effect of GEPU shocks on long-term volatilities of global equities, bonds, commodities, clean energy and Bitcoin. The GEPU-based volatility is used as a proxy for the uncertainty of the investor’s views in the Black-Litterman (BL) framework. Empirical results show that the BL model with GEPU-based views yields higher out-of-sample risk-adjusted returns than other traditional benchmarks in most cases. The findings suggest that investors should consider the influence of GEPU when making portfolio decisions.