已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Molecular characteristics and prognostic factors of leptomeningeal metastasis in non-small cell lung cancer

医学 ROS1型 内科学 克拉斯 T790米 肺癌 肿瘤科 脑转移 置信区间 胃肠病学 转移 癌症 腺癌 结直肠癌
作者
Xiaocui Liu,Guangrui Li,Hongmei Zhang,Qing Chang,Mei Fang,Chufan Lu,Panpan Tian,Feng-Jun Mei
出处
期刊:Clinical Neurology and Neurosurgery [Elsevier BV]
卷期号:225: 107572-107572 被引量:3
标识
DOI:10.1016/j.clineuro.2022.107572
摘要

Non-small cell lung cancer with leptomeningeal metastasis (NSCLC-LM) is emerging as a new management challenge for oncologists and is associated with poor prognosis. This study aimed to investigate the molecular characteristics and prognostic factors of NSCLC-LM.This retrospective study included 97 patients with NSCLC-LM between January 2015 and October 2021. Progression-free survival (PFS) and overall survival (OS) were evaluated. Gene mutations were detected by next-generation sequencing (NGS).The median PFS and OS were 8.4 (95 % confidence interval [CI]: 4.839-11.901) and 14.0 (95 % CI: 9.254-18.746) months, respectively. Sixty-seven patients harboured epidermal growth factor receptor-mutated (EGFRm): L858R (34), 19del (29), T790M (13), and G719C with L861Q (1). Other mutations included ALK (5), ROS1 (3), KRAS (1), TP53 (14), MET amplification (6). The detection rate and types of circulating tumour DNA (ctDNA) in the cerebrospinal fluid (CSF) samples were higher than the paired plasma samples. Patients with EGFR mutations had a longer median OS than those without mutations (19.0 vs. 13.0 months, P = 0.015). Patients with gene mutations had shorter median OS than those without mutations, such as ALK (11.8 vs. 19.9 months, P = 0.014), ROS1 (12.7 vs. 19.8 months, P = 0.014), KRAS (4.0 vs. 19.0 months, P = 0.005), TP53 (15.0 vs. 19.0 months, P = 0.014), and MET amplification (6.0 vs. 19.0 months, P = 0.003). Multivariate analysis indicated that MET amplification was an independent predictor of poor survival. Along with Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≥ 3, LM accompanied with brain parenchymal metastasis (BPM), extracranial disease, and seizures were independent predictors of poor survival, whereas intrathecal chemotherapy, and third-generation EGFR-TKIs were independent predictors of favorable survival.CSF ctDNA detected using NGS had a high sensitivity for NSCLC-LM, showing high potential in detecting driver and drug-resistant gene mutations. Genomic profiles, combined with clinically relevant prognostic factors, will guide individualised treatments and improve the outcomes of NSCLC-LM patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
水若琳发布了新的文献求助10
刚刚
早睡早起身体好完成签到,获得积分10
刚刚
白杨木影子被拉长完成签到,获得积分10
2秒前
YYYCCCCC完成签到,获得积分10
3秒前
眼睛大的薯片完成签到 ,获得积分10
4秒前
lunar完成签到 ,获得积分10
14秒前
高大的蜡烛完成签到,获得积分10
19秒前
芜湖起飞完成签到 ,获得积分10
22秒前
肃肃其羽完成签到 ,获得积分10
30秒前
山城小肘子完成签到,获得积分10
30秒前
陈尹蓝完成签到 ,获得积分10
31秒前
淡定的半梦完成签到,获得积分10
31秒前
HLZ完成签到,获得积分20
32秒前
哈哈环完成签到 ,获得积分10
33秒前
阿亞完成签到,获得积分10
33秒前
yunjian1583完成签到,获得积分10
37秒前
多多完成签到,获得积分10
47秒前
redamancy完成签到 ,获得积分10
47秒前
Vaseegara完成签到 ,获得积分10
50秒前
旷野发布了新的文献求助10
53秒前
上官若男应助科研通管家采纳,获得10
58秒前
田様应助科研通管家采纳,获得10
58秒前
慕青应助科研通管家采纳,获得10
58秒前
58秒前
wanci应助科研通管家采纳,获得10
59秒前
59秒前
汉堡包应助科研通管家采纳,获得10
59秒前
59秒前
59秒前
香蕉觅云应助科研通管家采纳,获得10
59秒前
清爽冬莲完成签到 ,获得积分10
1分钟前
gxl完成签到,获得积分10
1分钟前
浮尘完成签到 ,获得积分0
1分钟前
笨笨的荧荧完成签到 ,获得积分10
1分钟前
lizigongzhu发布了新的文献求助10
1分钟前
顺利问玉完成签到 ,获得积分10
1分钟前
Jasper应助科研达人采纳,获得10
1分钟前
蓬荜生辉完成签到,获得积分10
1分钟前
xinqianying完成签到 ,获得积分10
1分钟前
范户晓发布了新的文献求助10
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989989
求助须知:如何正确求助?哪些是违规求助? 3532034
关于积分的说明 11256053
捐赠科研通 3270900
什么是DOI,文献DOI怎么找? 1805105
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216