已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes

医学 糖尿病前期 维生素D与神经学 胆钙化醇 内科学 2型糖尿病 糖尿病 危险系数 安慰剂 空腹血糖受损 维生素D缺乏 内分泌学 置信区间 糖耐量受损 病理 替代医学
作者
Anastassios G. Pittas,Tetsuya Kawahara,Rolf Jorde,Bess Dawson‐Hughes,Ellen M. Vickery,Edith Angellotti,Jason Nelson,Thomas A Trikalinos,Ethan M Balk
出处
期刊:Annals of Internal Medicine [American College of Physicians]
卷期号:176 (3): 355-363 被引量:64
标识
DOI:10.7326/m22-3018
摘要

The role of vitamin D in people who are at risk for type 2 diabetes remains unclear.To evaluate whether administration of vitamin D decreases risk for diabetes among people with prediabetes.PubMed, Embase, and ClinicalTrials.gov from database inception through 9 December 2022.Eligible trials that were specifically designed and conducted to test the effects of oral vitamin D versus placebo on new-onset diabetes in adults with prediabetes.The primary outcome was time to event for new-onset diabetes. Secondary outcomes were regression to normal glucose regulation and adverse events. Prespecified analyses (both unadjusted and adjusted for key baseline variables) were conducted according to the intention-to-treat principle.Three randomized trials were included, which tested cholecalciferol, 20 000 IU (500 mcg) weekly; cholecalciferol, 4000 IU (100 mcg) daily; or eldecalcitol, 0.75 mcg daily, versus matching placebos. Trials were at low risk of bias. Vitamin D reduced risk for diabetes by 15% (hazard ratio, 0.85 [95% CI, 0.75 to 0.96]) in adjusted analyses, with a 3-year absolute risk reduction of 3.3% (CI, 0.6% to 6.0%). The effect of vitamin D did not differ in prespecified subgroups. Among participants assigned to the vitamin D group who maintained an intratrial mean serum 25-hydroxyvitamin D level of at least 125 nmol/L (≥50 ng/mL) compared with 50 to 74 nmol/L (20 to 29 ng/mL) during follow-up, cholecalciferol reduced risk for diabetes by 76% (hazard ratio, 0.24 [CI, 0.16 to 0.36]), with a 3-year absolute risk reduction of 18.1% (CI, 11.7% to 24.6%). Vitamin D increased the likelihood of regression to normal glucose regulation by 30% (rate ratio, 1.30 [CI, 1.16 to 1.46]). There was no evidence of difference in the rate ratios for adverse events (kidney stones: 1.17 [CI, 0.69 to 1.99]; hypercalcemia: 2.34 [CI, 0.83 to 6.66]; hypercalciuria: 1.65 [CI, 0.83 to 3.28]; death: 0.85 [CI, 0.31 to 2.36]).Studies of people with prediabetes do not apply to the general population. Trials may not have been powered for safety outcomes.In adults with prediabetes, vitamin D was effective in decreasing risk for diabetes.None. (PROSPERO: CRD42020163522).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
tiantian发布了新的文献求助10
2秒前
3秒前
小二郎应助洁净亦巧采纳,获得10
6秒前
royal完成签到 ,获得积分10
7秒前
8R60d8应助英勇的小白菜采纳,获得10
11秒前
sciscisci完成签到 ,获得积分10
13秒前
15秒前
花痴的骁完成签到 ,获得积分10
17秒前
张凯发布了新的文献求助10
17秒前
離原发布了新的文献求助10
19秒前
22秒前
wanci应助咩咩采纳,获得10
28秒前
今后应助567采纳,获得10
29秒前
我想开兰博完成签到 ,获得积分10
31秒前
平淡的雁开完成签到 ,获得积分10
34秒前
orixero应助张凯采纳,获得10
36秒前
38秒前
snoopy448发布了新的文献求助10
42秒前
44秒前
内向的八宝粥完成签到 ,获得积分10
45秒前
洞悉完成签到,获得积分10
47秒前
ssjjzhou完成签到 ,获得积分10
47秒前
48秒前
充电宝应助哈哈哈哈哈采纳,获得10
48秒前
49秒前
567发布了新的文献求助10
52秒前
开摆完成签到 ,获得积分10
53秒前
英姑应助Joker采纳,获得10
55秒前
hm发布了新的文献求助10
55秒前
56秒前
little完成签到,获得积分10
57秒前
爆米花应助修脚大师采纳,获得10
57秒前
哈哈发布了新的文献求助10
1分钟前
1分钟前
Wyyyn发布了新的文献求助30
1分钟前
adearfish完成签到 ,获得积分10
1分钟前
scnuli发布了新的文献求助30
1分钟前
李健应助明理的踏歌采纳,获得10
1分钟前
1分钟前
Chemokin完成签到 ,获得积分10
1分钟前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
An Introduction to Geographical and Urban Economics: A Spiky World Book by Charles van Marrewijk, Harry Garretsen, and Steven Brakman 600
Diagnostic immunohistochemistry : theranostic and genomic applications 6th Edition 500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3154722
求助须知:如何正确求助?哪些是违规求助? 2805534
关于积分的说明 7865058
捐赠科研通 2463710
什么是DOI,文献DOI怎么找? 1311554
科研通“疑难数据库(出版商)”最低求助积分说明 629647
版权声明 601832