移植
器官移植
补体系统
补语(音乐)
医学
免疫学
功能(生物学)
获得性免疫系统
先天免疫系统
免疫系统
生物
表型
内科学
生物化学
互补
基因
进化生物学
作者
Justin A. Steggerda,Peter S. Heeger
出处
期刊:Transplantation
[Ovid Technologies (Wolters Kluwer)]
日期:2024-02-16
被引量:1
标识
DOI:10.1097/tp.0000000000004927
摘要
Transplantation is the ideal therapy for end-stage organ failure, but outcomes for all transplant organs are suboptimal, underscoring the need to develop novel approaches to improve graft survival and function. The complement system, traditionally considered a component of innate immunity, is now known to broadly control inflammation and crucially contribute to induction and function of adaptive T-cell and B-cell immune responses, including those induced by alloantigens. Interest of pharmaceutical industries in complement therapeutics for nontransplant indications and the understanding that the complement system contributes to solid organ transplantation injury through multiple mechanisms raise the possibility that targeting specific complement components could improve transplant outcomes and patient health. Here, we provide an overview of complement biology and review the roles and mechanisms through which the complement system is pathogenically linked to solid organ transplant injury. We then discuss how this knowledge has been translated into novel therapeutic strategies to improve organ transplant outcomes and identify areas for future investigation. Although the clinical application of complement-targeted therapies in transplantation remains in its infancy, the increasing availability of new agents in this arena provides a rich environment for potentially transformative translational transplant research.
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