Different doses of hyaluronic acid injections in patients with knee osteoarthritis: A multicenter, randomized, prospective, single-blind, clinical study

医学 沃马克 骨关节炎 可视模拟标度 生活质量(医疗保健) 随机对照试验 物理疗法 透明质酸 临床终点 临床试验 外科 内科学 替代医学 护理部 病理 解剖
作者
Demirhan Dıraçoğlu,Selim Sezikli,Bahar Dernek,Mustafa Aziz YILDIRIM,Ekin İlke Şen
出处
期刊:Journal of Back and Musculoskeletal Rehabilitation [IOS Press]
卷期号:37 (3): 629-639 被引量:1
标识
DOI:10.3233/bmr-230097
摘要

BACKGROUND: Many formulations and dosing regimens are available for hyaluronic acid (HA). OBJECTIVE: To compare different doses of linear, high-molecular weight (HMW) HA injections among patients with knee osteoarthritis (OA). METHODS: Hundred patients were included in this randomized, single-blinded trial and randomly divided into three HA injection groups. The first group received five weekly 20 mg HA injections, the second group received three weekly 32 mg HA injections, and the third group received a single 48 mg HA injection. Patients were evaluated at baseline, 1, 3, and 6 months after the last injection for pain, stiffness, and function using the visual analog scale (VAS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire. Quality of life, patient’s global assessment, and Timed Up and Go (TUG) test scores were also evaluated. RESULTS: There was significant improvement in the WOMAC, VAS-pain, quality of life, patient’s global assessment, and TUG test mean scores at all follow-up time points (p< 0.001). However, the groups showed no significant differences in WOMAC, VAS-activity pain, and patient global scores at any follow-up point. CONCLUSION: Intra-articular injections of different doses of linear HMW HA can improve pain, stiffness, function, and quality of life in patients suffering from knee OA over a six-month period.

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