槲皮素
Zeta电位
体内分布
生物相容性
材料科学
PLGA公司
纳米颗粒
药物输送
膜
肝损伤
纳米技术
药理学
生物物理学
抗氧化剂
体外
化学
生物化学
医学
生物
冶金
作者
Jinlu Shang,Tiantian Liang,Daiqing Wei,Feiyang Qin,Jinglei Yang,Yun Ye,Meiling Zhou
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2023-12-29
卷期号:35 (11): 115102-115102
被引量:1
标识
DOI:10.1088/1361-6528/ad1440
摘要
Abstract Quercetin (QU), a natural flavonoid with potent anti-inflammatory and antioxidant properties, holds promise in treating acute liver injury (ALI). Nonetheless, its limited solubility hampers its efficacy, and its systemic distribution lacks targeting, leading to off-target effects. To address these challenges, we developed macrophage membrane-coated quercetin-loaded PLGA nanoparticles (MVs-QU-NPs) for active ALI targeting. The resulting MVs-QU-NPs exhibited a spherical morphology with a clear core–shell structure. The average size and zeta potential were assessed as 141.70 ± 0.89 nm and –31.83 ± 0.76 mV, respectively. Further studies revealed sustained drug release characteristics from MVs-QU-NPs over a continuous period of 24 h. Moreover, these MVs-QU-NPs demonstrated excellent biocompatibility when tested on normal liver cells. The results of biodistribution analysis in ALI mice displayed the remarkable ALI-targeting ability of MVs-DiD-NPs, with the highest fluorescence intensity observed in liver tissue. This biomimetic approach combining macrophage membranes with nanoparticle delivery, holds great potential for targeted ALI treatment.
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