活性氧
纤维
炎症
神经毒性
渗透(战争)
生物物理学
体内
化学
神经科学
医学
生物
免疫学
生物化学
毒性
运筹学
工程类
生物技术
有机化学
作者
Jiefei Wang,Ping Shangguan,Xiaoyu Chen,Yong Zhong,Ming Lin,Mu He,Yi‐Sheng Liu,Yuan Zhou,Xiaobin Pang,Lulu Han,Mengya Lu,Xiao Wang,Yang Liu,Honghui Yang,Jingyun Chen,Chenhui Song,Jing Zhang,Xin Wang,Bingyang Shi,Ben Zhong Tang
标识
DOI:10.1038/s41467-024-44737-x
摘要
Abstract Toxic amyloid-beta (Aβ) plaque and harmful inflammation are two leading symptoms of Alzheimer’s disease (AD). However, precise AD therapy is unrealizable due to the lack of dual-targeting therapy function, poor BBB penetration, and low imaging sensitivity. Here, we design a near-infrared-II aggregation-induced emission (AIE) nanotheranostic for precise AD therapy. The anti-quenching emission at 1350 nm accurately monitors the in vivo BBB penetration and specifically binding of nanotheranostic with plaques. Triggered by reactive oxygen species (ROS), two encapsulated therapeutic-type AIE molecules are controllably released to activate a self-enhanced therapy program. One specifically inhibits the Aβ fibrils formation, degrades Aβ fibrils, and prevents the reaggregation via multi-competitive interactions that are verified by computational analysis, which further alleviates the inflammation. Another effectively scavenges ROS and inflammation to remodel the cerebral redox balance and enhances the therapy effect, together reversing the neurotoxicity and achieving effective behavioral and cognitive improvements in the female AD mice model.
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