Oleic acid differentially affects de novo lipogenesis and global lipid levels in hepatocytes

Liver disease has become a significant health concern worldwide with conditions such as obesity and liver cancer on the rise. Dysregulation of de novo lipogenesis (DNL) is a large factor in these diseases as it is the metabolic pathway responsible for the production of the majority of lipids in liver and adipose tissue. Free fatty acids (FFAs) also contribute in these diseases. While they are typically associated with hepatic steatosis and cell death, research suggests FFA may play a more complex role.