20 years of polybrominated diphenyl ethers on toxicity assessments

Polybrominated diphenyl ethers (PBDEs) serve as brominated flame retardants which continue to receive considerable attention because of their persistence, bioaccumulation, and potential toxicity. Although PBDEs have been restricted and phased out, large amounts of commercial products containing PBDEs are still in use and discarded annually. Consequently, PBDEs added to products can be released into our surrounding environments, particularly in aquatic systems, thus posing great risks to human health. Many studies and reviews have described the possible toxic effects of PBDEs, while few studies have comprehensively summarized and analyzed the global trends of their toxicity assessment. Therefore, this study utilizes bibliometrics to evaluate the worldwide scientific output of PBDE toxicity and analyze the hotspots and future trends of this field. Firstly, the basic information including the most contributing countries/institutions, journals, co-citations, influential authors, and keywords involved in PBDE toxicity assessment will be visualized. Subsequently, the potential toxicity of PBDE exposure to diverse systems, such as endocrine, reproductive, neural, and gastrointestinal tract systems, and related toxic mechanisms will be discussed. Finally, we conclude this review by outlining the current challenges and future perspectives in environmentally relevant PBDE exposure, potential carriers for PBDE transport, the fate of PBDEs in the environment and human bodies, advanced stem cell-derived organoid models for toxicity assessment, and promising omics technologies for obtaining toxic mechanisms. This review is expected to offer systematical insights into PBDE toxicity assessments and facilitate the development of PBDE-based research.