蝎子
毒液
环境化
肽
蝎子毒
抗蛇毒血清
脱颗粒
药理学
布提亚科
化学
生物
生物化学
受体
作者
Nathalia Baptista Dias,Bibiana Monson de Souza,Fernanda P. Cid,Valquíria Abrão Coronado Dorce,Fernando Kamimura Cocchi,Mário Sérgio Palma
标识
DOI:10.1021/acs.jnatprod.3c01085
摘要
Scorpion venoms are a rich source of bioactive peptides, most of which are neurotoxic, with 30 to 70 amino acid residues in their sequences. There are a scarcity of reports in the literature concerning the short linear peptides found in scorpion venoms. This type of peptide toxin may be selectively extracted from the venom using 50% (v/v) acetonitrile. The use of LC-MS and MS/MS enabled the detection of 12 bioactive short linear peptides, of which six were identified as cryptides. These peptides were shown to be multifunctional, causing hemolysis, mast cell degranulation and lysis, edema, pain, and anxiety, increasing the complexity of the envenomation mechanism. Apparently, the natural functions of these peptide toxins are to induce inflammation and discomfort in the victims of scorpion stings.
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