Gut Microbiota-Mediated Degradation of Food-Grade Lambda-Carrageenan by Bacteroides xylanisolvens and Its Role in Inflammation

炎症 拟杆菌 肠道菌群 背景(考古学) 卡拉胶 食品科学 化学 细菌 微生物学 生物 免疫学 生物化学 遗传学 古生物学
作者
Yanhui Han,Xiaojing Guo,Pongpol Thanuphol,Ruya Ji,Zhenjun Zhu,Yanyan Wu,Hengjun Du,Hang Xiao
出处
期刊:Journal of Agricultural and Food Chemistry [American Chemical Society]
标识
DOI:10.1021/acs.jafc.4c10159
摘要

Concerns about the safety of food additives have intensified among consumers, scientists, and policymakers. Ensuring the safety of these additives is crucial to public health. Carrageenan (CGN), a common additive in the food industry, has become the subject of controversy, particularly regarding whether it can be degraded in the gastrointestinal tract, forming degraded carrageenans (dCGNs) that may pose health risks. This study is among the first to identify Bacteroides xylanisolvens C3 as a key gut bacterium involved in the degradation of food-grade lambda-CGN (L-CGN). Using high-performance liquid chromatography (HPLC), thin-layer chromatography (TLC), and metabolic analysis, we confirmed the ability of this bacterium to degrade L-CGN. Importantly, we found that the microbiota-generated dCGNs significantly increased nitric oxide (NO) and COX-2 production and upregulated pro-inflammatory genes, including IL-1β, TNF-α, and IL-6, in macrophages. This study also highlights how microbial degradation of L-CGN can drive inflammation, particularly through the activation of the Nrf2 and NLRP3 pathways. These results suggest that microbial degradation of L-CGN in the gut may contribute to inflammation, underscoring the need to better understand microbial interactions with food-grade L-CGN, particularly in the context of colon health and inflammation-related diseases such as inflammatory bowel disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
1秒前
1秒前
1秒前
大模型应助不吃香菜采纳,获得10
2秒前
平淡水儿发布了新的文献求助10
2秒前
Ava应助lj采纳,获得10
2秒前
Xiyunyun发布了新的文献求助10
4秒前
一往而深发布了新的文献求助10
4秒前
王怜花发布了新的文献求助10
4秒前
5秒前
5秒前
7秒前
ll完成签到,获得积分10
7秒前
小郑完成签到,获得积分10
8秒前
坦率的松完成签到,获得积分10
8秒前
赘婿应助Veronica采纳,获得10
9秒前
10秒前
10秒前
橙子快跑发布了新的文献求助10
11秒前
韬气包发布了新的文献求助10
11秒前
enli完成签到,获得积分10
12秒前
热情飞荷完成签到,获得积分10
13秒前
桐桐应助zzznznnn采纳,获得10
13秒前
13秒前
14秒前
殷勤的汝燕完成签到,获得积分20
14秒前
14秒前
15秒前
agnes发布了新的文献求助10
15秒前
fun发布了新的文献求助10
15秒前
17秒前
崔家荣发布了新的文献求助30
17秒前
刘仁轨发布了新的文献求助10
18秒前
Hello应助浮生采纳,获得10
18秒前
科研通AI5应助悦耳静枫采纳,获得10
18秒前
19秒前
浅希忆辰应助duan采纳,获得10
19秒前
19秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
Teaching language in context (Third edition) by Derewianka, Beverly; Jones, Pauline 550
Oligomycin, a new antifungal antibiotic 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3583447
求助须知:如何正确求助?哪些是违规求助? 3152668
关于积分的说明 9493793
捐赠科研通 2855215
什么是DOI,文献DOI怎么找? 1569480
邀请新用户注册赠送积分活动 735260
科研通“疑难数据库(出版商)”最低求助积分说明 721145