细胞内
聚合
癌细胞
化学
生物物理学
活性氧
细胞
纳米技术
材料科学
生物化学
聚合物
癌症
生物
有机化学
遗传学
作者
Chengfei Liu,Banruo Xianyu,Yiheng Dai,Shuojiong Pan,Tianyu Li,Huaping Xu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-06-07
卷期号:17 (12): 11905-11913
被引量:8
标识
DOI:10.1021/acsnano.3c03512
摘要
Polymerization inside living cells provides chemists with a multitude of possibilities to modulate cell activities. Considering the advantages of hyperbranched polymers, such as a large surface area for target sites and multilevel branched structures for resistance to the efflux effect, we reported a hyperbranched polymerization in living cells based on the oxidative polymerization of organotellurides and intracellular redox environment. The intracellular hyperbranched polymerization was triggered by reactive oxygen species (ROS) in the intracellular redox microenvironment, effectively disrupting antioxidant systems in cells by an interaction between Te (+4) and selenoproteins, thus inducing selective apoptosis of cancer cells. Importantly, the obtained hyperbranched polymer aggregated into branched nanostructures in cells, which could effectively evade drug pumps and decrease drug efflux, ensuring the polymerization for persistent treatment. Finally, in vitro and in vivo studies confirmed that our strategy presented selective anticancer efficacy and well biosafety. This approach provides a way for intracellular polymerization with desirable biological applications to regulate cell activities.
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