脂肪酸结合蛋白
细胞内
癌变
癌症研究
转录因子
前列腺癌
化学
生物化学
脂质代谢
结合蛋白
癌症
生物
医学
内科学
基因
作者
W. G. Warren,Mary Osborn,Andrew Yates,Karen L. Wright,Saoirse E. O’Sullivan
标识
DOI:10.1016/j.drudis.2023.103628
摘要
Fatty acid binding protein 5 (FABP5, or epidermal FABP) is an intracellular chaperone of fatty acid molecules that regulates lipid metabolism and cell growth. In patient-derived tumours, FABP5 expression is increased up to tenfold, often co-expressed with other cancer-related proteins. High tumoral FABP5 expression is associated with poor prognosis. FABP5 activates transcription factors (TFs) leading to increased expression of proteins involved in tumorigenesis. Genetic and pharmacological preclinical studies show that inhibiting FABP5 reduces protumoral markers, whereas elevation of FABP5 promotes tumour growth and spread. Thus, FABP5 might be a valid target for novel therapeutics. The evidence base is currently strongest for liver, prostate, breast, and brain cancers, and squamous cell carcinoma (SCC), which could represent relevant patient populations for any drug discovery programme.
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