Objectives: Owing to widespread mask use during the COVID-19 pandemic and clinical reports tying mask use with dryness, this study endeavors to determine if mask use is linked to symptoms of dry eye. Methods: A prospective, cross-sectional survey study was performed. The survey used a modified Standard Patient Evaluation of Eye Dryness Questionnaire (SPEED, TearScience, Morrisville, NC) within 15 min of the beginning and discontinuation of mask wear. The survey also asked about mask wear time, mask style, visual correction, age, and gender. Results: The change in SPEED scores was statistically significant ( P =0.03) between participants with mild SPEED score at baseline (0–9) versus severe SPEED score at baseline (10–28) (n=77: 59 female, 16 male, 1 nonbinary, and 1 declined to answer; range 22–55 years old). Participants in the severe group used masks with nose wire more than the mild group ( P =0.03). Conclusions: In this sample, dry eye symptoms were most exacerbated with mask wear in those that had mild initial symptom scores compared with those with severe symptom scores at baseline. The use of nose wire masks may be protective, as the severe group used this type more and had significantly less exacerbation of symptoms postmask wear.