Risk of limb amputation and bone fractures with sodium glucose cotransporter-2 inhibitors: a Network Meta-analysis and Meta-regression

Sodium glucose cotransporter-2 inhibitors (SGLT2is) have gained immense attention for a variety of indications. Limb amputations (LA) and fractures were reported in clinical trials. This network meta-analysis and meta-regression were carried out to quantify the risks of these events.