Improved Disease-Specific Survival in Lentigo Maligna Treated with Mohs Surgery over Wide Local Excision: A Retrospective Cohort Analysis

Lentigo maligna (LM), a subtype of melanoma in-situ, typically occurs on sun-damaged skin of the head and neck in older males. Using the SEER database, the aim of this study was to compare disease-specific survival (DSS) outcomes between patients treated with wide local excision (WLE) and Mohs micrographic surgery (MMS), finding that MMS demonstrated improved 5- and 10-year DSS rates and a lower disease-specific mortality risk than WLE on multivariable analysis. Our findings highlight a potential DSS benefit of MMS for treating LM, although further research is required to confirm these findings and explore factors influencing treatment choices.