医学
肺纤维化
纤维化
Toll样受体
特发性肺纤维化
转化研究
受体
免疫学
肺
内科学
病理
先天免疫系统
作者
Glenda Trujillo,Alicia Regueiro‐Ren,Chunjian Liu,Buqu Hu,Ying Sun,Farida Ahangari,V. Fiorini,Genta Ishikawa,Karam Al Jumaily,Johad Khoury,John McGovern,Chris Lee,Xue Yan Peng,Taylor Pivarnik,Huanxing Sun,Anjali Walia,Samuel Woo,Sheeline Yu,Danielle Antin‐Ozerkis,Maor Sauler
标识
DOI：10.1164/rccm.202401-0065oc
摘要
In this novel study, we found that direct TLR9 inhibition mitigates fibroproliferative responses in preclinical models of pulmonary fibrosis. Our work demonstrates the therapeutic potential of direct TLR9 antagonism in IPF and related fibrotic lung diseases.
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(2025-6-4)
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